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2025 NFL Week 12 Expert Picks

That the Panthers are 6-5 after 11 weeks is one of the more surprising records in the league this year. But here’s an even bigger surprise: Carolina is 7-4 against the spread. 

While the 49ers have impressed with their resilience in the face of a never-ending onslaught of injuries, the team has the third-worst defensive success rate in the league. The Niners have allowed 306 passing yards and 3.5 passing touchdowns per game with a completion percentage against north of 75 percent over the last month.

Bryce Young keeps this one close. 

At 6-5, the Panthers look like a team that’s on the rise, but they’re pretenders. Sure, they went on the road to beat the Green Bay Packers, who have struggled offensively, and swept their season series with the three-win Atlanta Falcons. However, San Francisco is a team with an established offensive identity.

Expect Christian McCaffrey to post gaudy rushing numbers in the first game against his former team.

The Panthers have allowed an average of 149 rushing yards over the last four weeks. Don’t be surprised if McCaffrey surpasses that number in the bright lights of Monday Night Football.  

Panthers: Davenport, Sobleski

49ers: Gagnon, Hanford, Knox, Moton, O’Donnell

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