J.T. Compher and Jonatan Berggren each had a goal and an assist, and Andrew Copp had two assists for Detroit (6-3-0), which trailed 4-0 midway through the second period. John Gibson made 25 saves.
Jake Neighbours scored twice for the Blues (3-4-1), who are 0-2-1 in their past three games. Justin Faulk, Jimmy Snuggerud and Robert Thomas each had two assists, and Jordan Binnington made 22 saves.
Berggren’s power-play goal pulled Detroit within 4-1 at 7:52 of the second period.
The Red Wings then scored twice in 27 seconds to make it 4-3. Emmitt Finnie swatted home a loose puck for his fourth NHL goal at 18:34 before Compher tipped Travis Hamonic’s shot out of the air at 19:01.
Alex DeBrincat tied it 4-4 at 10:01 of the third, finishing off a solo rush with a wrist shot from the top of the slot for his first goal of the season.
Edvinsson gave Detroit a 5-4 lead at 10:48 with a shot from the left point that deflected off St. Louis forward Brayden Schenn and went inside the left post, then scored an empty-net goal at 18:47 for the 6-4 final.
The Blues took a 1-0 lead on a power-play goal from Jordan Kyrou at 7:43.
Neighbours made it 2-0 at 12:54, tapping Faulk’s pass past Gibson.
St. Louis expanded the lead to 3-0 with its second power-play goal of the game at 59 seconds of the second period when Pavel Buchnevich redirected Dylan Holloway’s pass over Gibson’s shoulder.
Neighbors scored his sixth goal in eight games this season to make it 4-0 at 3:12.
Thomas left the game with an upper-body injury at 2:02 of the third.
