A week of celebrations will begin at game 499, the World Cup qualifier with Spain at Wembley Stadium on Tuesday.
More than 50 former Lionesses from across the decades will be in attendance and will form a guard of honour as both teams walk out onto the pitch, said the FA.
England captain Leah Williamson said: “As we reach the 500th game it feels more important than ever to honour every former Lioness and those who had to play in the shadows prior.
“We are the lucky ones, we get to play with opportunities they could only dream of,” she added.
“The trailblazers who played with passion and determination broke boundaries and built the foundations we stand on today.”
