Astros vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for June 21

Odds updated as of 9:12 p.m.

On Sunday in MLB, the Houston Astros are playing the Cleveland Guardians.

Here’s everything you need to know before checking out today’s MLB odds and spreads on FanDuel Sportsbook.

• Houston Astros (36-41) vs. Cleveland Guardians (40-36)
• Date: Sunday, June 21, 2026
• Time: 2:10 p.m. ET
• Venue: Daikin Park — Houston, Texas
• Coverage: SCHN and CleGuardians.TV

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-142) | CLE: (+120)
• Spread: HOU: -1.5 (+155) | CLE: +1.5 (-188)
• Total: 8.5 — Over: (-112) | Under: (-108)

Astros vs Guardians Probable Starting Pitchers

Probable Pitchers: Kai-Wei Teng (Astros) – 3-6, 4.31 ERA vs Slade Cecconi (Guardians) – 3-5, 4.60 ERA

The Astros will call on Kai-Wei Teng (3-6) versus the Guardians and Slade Cecconi (3-5). Teng’s team is 3-5-0 against the spread in his starts this season. Teng’s team has been upset in each of the three games he’s started as the moneyline favorite. The Guardians have gone 6-7-0 ATS in Cecconi’s 13 starts with a set spread. The Guardians are 2-8 in Cecconi’s 10 starts this season that they were the underdog on the moneyline.

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (55.4%)

• Cleveland is the underdog, +120 on the moneyline, while Houston is a -142 favorite at home.

• The Astros are hosting the Guardians and are favored by 1.5 runs on the spread. The Astros are +155 to cover the runline, with the Guardians being -188.

• An over/under of 8.5 has been set for Astros-Guardians on June 21, with the over being -112 and the under -108.

Bet on Houston Astros vs. Cleveland Guardians on FanDuel today!

• The Astros have come away with 11 wins in the 25 contests they have been listed as the favorites in this season.
• This season Houston has been victorious five times in 12 chances when named as a favorite of at least -142 on the moneyline.
• The Astros and their opponents have gone over the total this season in 41 of their 77 opportunities.
• The Astros are 36-41-0 against the spread in their 77 games that had a posted line this season.
• The Guardians have been the moneyline underdog 34 total times this season. They’ve finished 18-16 in those games.
• When it has played as a moneyline underdog with odds of +120 or longer, Cleveland has a record of 8-7 (53.3%).
• The Guardians have had an over/under set by oddsmakers 72 times, and have combined with opponents to go over the total in 36 of those games (36-36-0).
• The Guardians have a 37-35-0 record against the spread this season (covering 51.4% of the time).

Astros Player Leaders

• Yordan Alvarez has 90 hits and an OBP of .428 to go with a slugging percentage of .637. All three of those stats are tops among Houston hitters this season. He has a .324 batting average, as well.
• Among qualifying batters, he ranks third in batting average, his on-base percentage ranks second, and he is first in slugging.
• Alvarez will look for his 10th straight game with a hit in this contest. In his last 10 games he is batting .366 with two doubles, two home runs, three walks and seven RBIs.
• Christian Walker is hitting .242 with 14 doubles, a triple, 18 home runs and 26 walks, while slugging .488 with an on-base percentage of .313.
• Among all qualifying players, he is 99th in batting average, 108th in on-base percentage and 32nd in slugging percentage.
• Isaac Paredes has collected 59 base hits, an OBP of .344 and a slugging percentage of .415 this season.
• Paredes has recorded at least one base hit in four straight games. In his last five games he is batting .313 with two doubles, a home run, three walks and three RBIs.
• Jeremy Pena has six home runs, 18 RBI and a batting average of .289 this season.
• Pena heads into this game on a four-game hitting streak. During his last five outings he is hitting .348 with a double, three home runs and six RBIs.

• Brayan Rocchio has accumulated a team-best OBP (.353) and slugging percentage (.399). He’s batting .273.
• Including all the qualifying hitters in the majors, he ranks 49th in batting average, 49th in on-base percentage and 100th in slugging percentage.
• Steven Kwan has eight doubles, a home run and 37 walks while hitting .210. He’s slugging .256 with an on-base percentage of .319.
• Including all qualifying players, he is 145th in batting average, 98th in on-base percentage and 157th in slugging percentage.
• Travis Bazzana is batting .256 with 11 doubles, a triple, five home runs and 24 walks.
• Rhys Hoskins is batting .179 with 12 doubles, seven home runs and 35 walks.

• 6/19/2026: 9-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/22/2026: 2-0 HOU (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/21/2026: 8-5 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/20/2026: 9-2 HOU (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/9/2025: 4-2 CLE (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/8/2025: 10-6 CLE (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 7/7/2025: 7-5 CLE (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/8/2025: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 6/7/2025: 5-3 HOU (Favorite: Astros, Spread: -1.5, Total: 7, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/6/2025: 4-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)

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