Portland Police said in a statement that their officers were not involved in the incident, and were called after receiving reports that a man had been shot.
The two people who were shot have not identified, and police say they were discovered several blocks away from the scene of the shooting.
“Officers applied a tourniquet and summoned emergency medical personnel,” before they were taken to hospital, the statement says, adding that “their conditions are unknown”.
“We are still in the early stages of this incident,” said Portland Police Chief Bob Day.
“We understand the heightened emotion and tension many are feeling in the wake of the shooting in Minneapolis, but I am asking the community to remain calm as we work to learn more.”
Portland Mayor Keith Wilson also released a statement, saying that the shooting comes “just one day after the horrific violence in Minnesota at the hands of federal agents”.
He added that immigration agents should “end all operations in Portland until a full investigation can be completed”.
“Federal militarization undermines effective, community‑based public safety, and it runs counter to the values that define our region,” he said.
Portland has been the site of large anti-Trump protests in the past.
On Wednesday night, Portland police arrested one protester who was charged with menacing after officers found him allegedly threatening another person with a knife.
