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2026 NFL schedule release: Bills to host Lions on ‘Thursday Night Football’ on Prime Video in Week 2

The Bills are coming off a 12-5 campaign, a down season by their standards, losing in the Divisional Round after making the playoffs as a wild-card team. It broke a streak of five straight AFC East titles. Meanwhile, the Lions are likewise following up a 9-8 campaign in which they plummeted from atop the NFC North to the cellar.

The Week 2 matchup could be ripe for fireworks in the Bills’ new home. 2024 NFL MVP Josh Allen, 2025 league rushing champion James Cook, and new receiver DJ Moore bring pop under rookie head coach Joe Brady. Jared Goff, Jahmyr Gibbs, Amon-Ra St. Brown, Jameson Williams and the explosive Lions offense take on a revamped Bills defense under new defensive coordinator Jim Leonhard. Prime Video might be in for a high-scoring tussle to open its season slate.

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