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Diamondbacks vs Giants Prediction, Odds & Player Prop Bets Today – MLB, May 25

  • The Giants are -140 favorites vs the Diamondbacks
  • Diamondbacks vs Giants Over / Under today: 7.5 Runs
  • Diamondbacks / Giants TV Channel: NSBA | DBTV

The Arizona Diamondbacks (+115) visit Oracle Park to take on the San Francisco Giants (-140) on May 25, 2026. First pitch is scheduled for 5:05 pm in San Francisco, CA.

This season, the Diamondbacks are 28-24 against the spread (ATS), while the Giants are 22-30 ATS.

Diamondbacks vs Giants Starting Pitchers Today:

  • Diamondbacks starting pitcher: Merrill Kelly 4-3, 5.67 ERA
  • Giants starting pitcher: Landen Roupp 5-4, 3.30 ERA

Diamondbacks vs. Giants Odds, Run Line, Over/Under & Moneyline

SpreadOver / UnderMoneylineDiamondbacks+1.5 -190O 7.5 -105+115Giants -1.5 +155U 7.5 -115-140

Based on recent trends the model predicts the Giants will win Monday‘s MLB game with 58.9% confidence, factoring in game simulations, recent player performances, starting pitchers and injuries.

Bet now on Diamondbacks vs Giants and all games with BetMGM

We’ve highlighted some favorite MLB player prop bets for Diamondbacks players for Monday‘s game, looking at profitable historical betting trends:

Best Diamondbacks Player Prop Bets Today:

  • Ildemaro Vargas has hit the Hits Runs and RBIs Over in 18 of his last 25 away games (+11.15 Units / 41% ROI)
  • Ildemaro Vargas has hit the Singles Over in 19 of his last 25 away games (+10.90 Units / 33% ROI)
  • Ildemaro Vargas has hit the Hits Over in 15 of his last 20 away games (+8.40 Units / 24% ROI)
  • Ketel Marte has hit the RBIs Under in his last 8 away games (+8.00 Units / 51% ROI)
  • Corbin Carroll has hit the Walks Over in 6 of his last 7 away games (+6.35 Units / 89% ROI)

And here are some favorite MLB player prop bets for Giants players for Monday‘s game, looking at profitable historical betting trends:

Best Giants Player Prop Best Bets Today:

  • Bryce Eldridge has hit the Singles Under in 16 of his last 20 games (+9.40 Units / 27% ROI)
  • Bryce Eldridge has hit the Hits Under in 13 of his last 20 games (+8.50 Units / 41% ROI)
  • Bryce Eldridge has hit the Hits Runs and RBIs Under in 14 of his last 20 games (+7.20 Units / 29% ROI)
  • Landen Roupp has hit the Walks Allowed Under in 11 of his last 15 games (+7.10 Units / 35% ROI)
  • Landen Roupp has hit the Strikeouts Over in 11 of his last 15 games (+6.80 Units / 37% ROI)

Diamondbacks Against the Spread (ATS) Record

Against the spread this season, the Diamondbacks are 31-20 against the Run Line (+5.25 Units / 7.41% ROI).

  • 28-24 when betting on the Moneyline for +2.4 Units / 4% ROI
  • 26-24 when betting on the total runs Over for -1.35 Units / -2.4% ROI
  • 24-26 when betting on the total runs Under for -3.3 Units / -5.9% ROI

Giants Against the Spread (ATS) Record

Against the spread this season, the Giants are 22-30 against the Run Line (-20.65 Units / -27.5% ROI).

  • 22-31 when betting on the Moneyline for -7.55 Units / -13.51% ROI
  • 25-25 when betting on the total runs Over for -3.45 Units / -6.02% ROI
  • 25-25 when betting on the total runs Under for -1.3 Units / -2.28% ROI

Giants vs Diamondbacks Home Run Prop Bets Today

Giants vs Diamondbacks Total Hits Prop Bets Today

Giants vs Diamondbacks Strikeout Prop Bets Today

Diamondbacks Keys to the Game vs. the Giants

The Diamondbacks are 5-15 (.250) when trailing entering the 7th inning this season — 2nd best in MLB; League Avg: .137.

The Diamondbacks are just 82-22 (.788) when leading entering the 7th inning since the 2025 season — 2nd lowest in MLB; League Avg: .872.

The Diamondbacks are just 90-16 (.849) when leading entering the 8th inning since the 2025 season — 2nd lowest in MLB; League Avg: .906.

The Diamondbacks are 7-84 (.077) when trailing entering the 9th inning since the 2025 season — 3rd best in MLB; League Avg: .046.

Giants Keys to the Game vs. the Diamondbacks

The Giants are just 5-29 (.147) when scoring 4 or fewer runs this season — lowest in MLB; League Avg: .283.

The Giants are 10-0 (1.000) when they’ve had 5 or more XBH this season — tied for best in MLB; League Avg: .791.

The Giants are just 0-27 (.000) when trailing entering the 9th inning this season — tied for lowest in MLB; League Avg: .053.

The Giants are just 16-5 (.762) when leading entering the 7th inning this season — 2nd lowest in MLB; League Avg: .863.

Diamondbacks hitters have struck out in just 17% of their PA’s against LHP this season — best in MLB.

The Diamondbacks are batting .351 in lefty-lefty matchups this season — best in MLB.

The Diamondbacks are batting .282 against LHP this season — best in MLB.

Diamondbacks hitters are slugging .452 against LHP this season — 2nd best in MLB.

Giants hitters have drawn walks in 6% of their PA’s against RHP this season — lowest in MLB.

The Giants have an average HR distance of 379.3 feet this season — lowest in MLB.

Giants hitter’ K:BB ratio is 3.8 against RHP this season — highest in MLB.

Giants hitters have drawn walks in 6% of their PA’s this season — lowest in MLB.

Diamondbacks pitchers have walked 6% of batters when facing the leadoff batter in the inning this season — 2nd best in MLB.

Opponents have a miss rate of just 23% against Diamondbacks pitchers this season — tied for 2nd lowest in MLB.

Diamondbacks pitchers have walked 8% of batters this season — 4th best in MLB.

Diamondbacks pitchers have struck out just 18% of left-handed batters they faced this season — lowest in MLB.

Opponents have a groundball rate of 48% against Giants pitchers this season — 2nd highest in MLB.

Giants pitchers have thrown at least two strikes in their first three pitches to 56% of opposing batters this season — lowest in MLB.

Giants pitchers have induced opposing hitters to ground into 49 double plays in 391 opportunities (12%) this season — best in MLB.

Opponents have a groundball batting average of just .214 against Giants pitchers this season — 2nd best in MLB.

More MLB Reading:

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