In Eastbourne, British qualifier Giles Hussey stunned French Open semi-finalist Matteo Arnaldi to reach the second round.
The 293rd-ranked Hussey beat world number 30 Arnaldi 6-4 6-2 to set up a meeting with Frenchman Quentin Halys.
Arnaldi, 29, was playing his first tournament since being forced to withdraw before his last-four match at Roland Garros with illness.
Hussey won his first Challenger title in South Africa last month and secured straight-set wins over 78th-ranked James Duckworth and world number 94 Marco Trungelliti to qualify for just the second ATP Tour event of his career.
Britain’s Arthur Fery, a quarter-finalist at Queen’s last week, continued his recent good form with a 6-2 4-6 7-5 win over Argentina’s Roman Andres Burruchaga.
In the women’s draw, Italy’s top seed Jasmine Paolini was beaten 6-4 6-3 by Germany’s Tatjana Maria, who won the Queen’s title last year.
In the men’s doubles, Briton Joe Salisbury and American Rajeev Ram, who have reunited after a successful partnership from 2018 to 2024, won their opening match.
Salisbury and Ram, who have won four major trophies together, prevailed 6-1 6-3 against French duo Terence Atmane and Luca Sanchez.
