He added: “I am quite relaxed. I am sure as we get closer to the game it will become more nerve-wracking. I haven’t worked at this level before but the lads have been brilliant and we will do this together.”
Maresca’s departure came after a 2-2 draw against Bournemouth on Tuesday, which left the Blues 15 points adrift of leaders Arsenal.
It means McFarlane’s debut as a manager of a senior team will come against Pep Guardiola, who celebrated managing his 1,000th match as a head coach in November.
“The team needs to be ready and prepared and our role is giving the players the support they need to go and execute,” he said.
“I wouldn’t say we have nothing to lose. We have to give a real good account of ourselves.”
Chelsea travel to Manchester three places and 11 points behind second-placed City.
Reports following Maresca’s departure suggested the Italian had held talks over succeeding Guardiola, though the former Leicester City boss denied the claims.
“From my point of view Chelsea have lost an incredible manager and an incredible person,” Guardiola said on Maresca’s departure.
“It’s a decision from the Chelsea hierarchy so I’ve nothing to say. How lucky I am in the club where I am. My club is extraordinary.”
Asked about his own future, Guardiola – whose current deal runs until the end of the 2026-27 season – said: “I have one more year.
“I’ve been here for 10 years and I promise you I will leave one day but I have a contract, I’m happy, I want to fight with my team, the hierarchy respect me – they proved last season when we didn’t win one game in three months.”
