The Chicago White Sox (14-17) and San Diego Padres (19-11) meet Friday for the opener of a 3-game series at Petco Park in San Diego, California. First pitch is at 9:40 p.m. ET. Let’s analyze MLB odds around the White Sox vs. Padres and make our expert MLB picks and predictions for the best bets.
2025 season series: Padres 2-1
The White Sox are coming off a 3-2 home win over the Los Angeles Angels as +100 underdogs Wednesday with the Under (8.5) cashing. DH Austin Hays went 2-for-5 and LF Sam Antonacci reached base twice with a triple and walk and also drove in a run as Chicago completed a 3-game sweep.
The Padres lost 5-4 against the Chicago Cubs as -112 home favorites Wednesday with the Over (8.5) cashing. LF Nick Castellanos hit a home run and reached base with a walk while driving in 2 in the loss. San Diego lost the series to the Cubs 2-1.
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White Sox at Padres projected starters
LHP Noah Schultz vs. RHP German Marquez
Schultz (1-1, 3.52 ERA) makes his fourth start. He has a 1.10 WHIP, 5.3 BB/9 and 10.6 K/9 through 15 1/3 innings.
- Last start: No-decision, 6 IP, 2 ER, 4 H, 4 BB, 8 K in a 6-3 home loss vs. Washington Nationals April 25
- First career start vs. Padres
- 2026 on road: 1 start, 1-0, 5 IP, 1 ER, 1 H, 1 BB, 6 K
Marquez (3-1, 4.38 ERA) makes his sixth start. He has a 1.34 WHIP, 2.6 BB/9 and 6.2 K/9 through 24 2/3 innings.
- Last start: Win, 6 IP, 4 ER, 6 H, 1 BB, 2 K in a 6-4 road victory at Arizona Diamondbacks on Saturday
- Career vs. White Sox: 1-2, 4.74 ERA (19 IP, 10 ER), 1.53 WHIP, 6.2 K/9 in 3 starts
- 2026 at home: 2 starts, 1-1, 8 IP, 8 ER, 12 H, 3 BB, 6 K
White Sox at Padres odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Friday at 3:15 p.m. ET.
- Moneyline (ML): White Sox +120 (bet $100 to win $xxx) | Padres -145 (bet $xxx to win $100)
- Run line (RL)/Against the spread (ATS): White Sox +1.5 (-185) | Padres -1.5 (+105)
- Over/Under (O/U): 8.0 (O: -118 | U: -102)
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White Sox at Padres picks and predictions
Prediction
White Sox 5, Padres 4
BET WHITE SOX +120.
These teams are trending in opposite directions, as the White Sox have won 3 in a row and 7 of their last 10 while the Padres have lost 2 in a row and 4 of their last 7. Schultz is a top-tier pitching prospect and coming off an 8-strikeout performance. Marquez has been bailed out by good run support from San Diego’s offense. I think it’s worthwhile to take a gamble on Chicago in this matchup.
PASS.
BET OVER 8 (-118).
Both teams are 5-5 on the Over/Under during their last 10 games. The Padres have hit the Over in 5 of their last 6 games.
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